If you are a diabetic, then you must know how to prepare and administer an injection. However, there are a few points that are not universally known.
If a small amount of insulin occasionally leaks out after an injection, try waiting a few seconds extra before removing the needle. These extra seconds may enable the insulin to diffuse into adjacent tissue, thereby minimizing or eliminating leakage.
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The site of the injection matters. Many years ago Val advised her endocrinologist that there seemed to be a difference in effectiveness depending upon the injection site. The abdomen seemed to work best, then the arms, and lastly the upper legs. Subsequent studies utilizing radio-labeled insulin proved this to be correct.
One study suggests that absorption from the upper abdomen. is more rapid than absorption from the lower abdomen (below the umbilicus).
Activity can influence insulin absorption quite significantly. If you take an injection in the arm, and then exercise with that arm, the blood flow to the arm will increase, accelerating absorption. Similarly, insulin absorptioin in the legs will increase with activity.
However, the absorption of Glargine insulin (Lantus) is NOT influenced by exercise.
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Subcutaneous body fat influences absorption. Larger amounts of subcutaneous fat are associated with slower absorption.